Structure, properties, spectra, suppliers and links for. The primary hazard is from blast of an instantaneous explosion and not flying projectiles and fragments. It is primarily used as an antiseptic, but has a number of uses in industry, in the manufacture of explosives and herbicides, and it is considered to be an industrial pollutant. The metabolic rate of the poisoned individual can increase markedly, and the body temperature is elevated. Dnp 2,4dinitrophenol is a chemical product that was historically used as an antiseptic, herbicide, and explosive. The warning concerns 2,4dinitrophenol dnp, a combination of compounds that increases body temperature and. Dnp is sold mostly over the internet under a number of different names as a weight lossslimming aid. A weight loss agent with significant acute toxicity and risk of death, however in studies of intermediateduration oral exposure to 2, 4 dnp, cases of death from agranulocytosis described in the discussion of hematological effects have been attributed to.
It sublimes, is volatile with steam, and is soluble in most organic solvents as well as aqueous alkaline solutions. Pdf two deaths attributed to the use of 2,4dinitrophenol. This material does not contain any class 2 ozone depletors. Background2,4dinitrophenol 2,4dnp is an effective but highly dangerous fat burner, not licensed for human consumption. Links to pubmed are also available for selected references. Yellow jasper tumbled gemstone 1 lb trjy16 average size 1 2 inch rocks approximately 3035 pieces per pound please allow for slight size, shape and color variations as this is a natural product. Reason for citation 2,4dinitrophenol is on the hazardous substance list because it is cited by epa. Shindler1 1scheie eye institute and fm kirby center for molecular ophthalmology, university of pennsylvania, philadelphia, pa 19104, usa. Strictly speaking, the former is more correct, though the latter is commonly used to refer to it too. It is a yellow, crystalline solid that has a sweet, musty. Make sure you are using the same usb port for the bluetooth connector each time. It is a yellow, crystalline solid that has a sweet, musty odor.
A weight loss agent with significant acute toxicity and risk of death, however in studies of intermediateduration oral exposure to 2,4dnp, cases of death from agranulocytosis described in the discussion of hematological effects have been attributed to. The substance identity section is calculated from substance identification information from all echa databases. The primary function of dnp is to increase heat production in the body cells to make them less efficient with energy. Dnp is also abused as a fat loss aid by dieters and bodybuilders. Mitochondrial uncoupler prodrug of 2,4dinitrophenol, mp201, prevents neuronal damage and preserves vision in experimental optic neuritis reas s. Youve probably seen 2,4dinitrophenylhydrazine referred to alternately as 2,4dnph or 2,4dnp. Table of contents 1 history 2 how it works 3 bodybuilding 4 side effects 5.
Nevertheless, an explosion in a munitions factory at rainham in essex in 1916 was attributed to 2,4dinitrophenol. Jan 10, 2004 this study found that antibioticresistant bacteria could be thwarted with dnp. Uses the predominant use of 2, 4 dinitrotoluene is as an intermediate in the manufacture of polyurethanes. It is volatile with steam and is soluble in most organic solvents as well as aqueous alkaline solutions. So while it goes work well at burning fat, youre ingesting an industrial poison to do so, and that is no hyperbole. There is no compound on earth that can burn fat at the rate of dnp. The pillbased pesticide was a substance known as dnpor 2,4dinitrophenol to you chemistsand was first used for the production of ammunition in france in world war i. To access the polyvision driver, click the show hidden icons double. Im including everything i have whether i agree with it or not, because there is no one right way to run dnp. Chronic oral exposure to 2, 4 dinitrophenol in humans and animals has resulted in the formation of cataracts and skin lesions and has caused effects on the bone marrow, cns, and cardiovascular system.
Dnp, officially labeled as 2,4dinitrophenol, is classified as an industrial chemical. The mechanism of uncoupling of oxidative phosphorylation by 2. Other applications include uses as an intermediate in dye processes and in smokeless gunpowders. Identification 2, 4 dinitrophenol is a yellow crystalline sandlike solid but is often found in a solution.
Product is supplied moist with water since the dry powder may be susceptible to. Before the first cycle i was 226, about 18% bodyfat, right now i have 2 more days left and i am at 210, will have an accurate estimate of bodyfat once the water is gone. Chronic longterm oral exposure to 2,4dinitrophenol in humans has resulted in the formation of cataracts and skin lesions, weight loss, and has caused effects on the bone marrow, central nervous system cns, and cardiovascular system. Nitrophenols 2,4dinitrophenol elevates the bmr, lowers the serum t4 concentration, accelerates the peripheral metabolism of t4, and depresses thyroidal raiu and secretion. I am now ending my 2nd dnp cycle, i did a 7 day, took 2 weeks off, and now finishing a 9 day cycle. Nov 16, 2012 new highly selective method is suggested for synthesis of 2, 4 dinitrophenol by nitration of phenol with nitric acid in an aqueousalcoholic medium at the boiling point of the reaction mixture.
I didnt know that she had been taking it until after she had died. Buy high purity 2,4dinitrophenol solution analytical standards from chem service inc. The chemical structure of 2, 4 dinitrophenol is shown in figure 1. Dnp 2,4 dinitrophenol info with all the dnp threads ive seen lately i thought it would be a good idea to post my compilation of dnp info. However, 2,4dnp can also refer to 2,4dinitrophenol, which isnt the specific chemical being discussed in this. Although dnp has yielded proven results when it comes to weight loss, even small overdoses have been reported to result in death. This is not only overkill but it is also extremely dangerous, as 1gday moving into stable blood levels can put you either just below. The mechanism of uncoupling of oxidative phosphorylation. Dermatitis may be due to either primary irritation or allergic sensitivity. Like tnt, it was found to be toxic to the munition workers handling it. The 2,4dinitrophenol dnp is a highly toxic yet highly effective solution for weight loss.
This is not only overkill but it is also extremely dangerous, as 1gday moving into stable blood levels can put you either just below, at, or above the overdose limit depending on your weight. This iris health assessment for 2,4dinitrophenol consists of hazard identification and doseresponse assessment data which provides support for epa risk management decisions. You can choose the one which is the most convenient or cost effective for you. May 06, 2015 global warning over dangerous diet drug.
Tragedy of the gifted rugby player, 18, who died after buying deadly fatburning pills online, the daily mail reports. Proline and heretic, 2 good bros i would take advice from anyday. Like t4, the drug stimulates metabolism by uncoupling oxidative phosphorylation in mitochondria. O 2,4dinitrofenol e rapidamente adsorvido atraves do trato gastrointestinal, bem com pela pele e pulmoes. Dnp 2,4dinitrophenol dnp was first introduced to the bodybuilding world by dan duchaine. The results from these studies, however, have shown a multiplicity of effects that suggest a more complicated interaction with the mtx transport system than adenosine 5. Buy high purity 2, 4 dinitrophenol solution analytical standards from chem service inc. For additional information on the health effects of this chemical, interested parties are referred to the. Buy dnp 2, 4 dinitrophenol not for human consumption. A wide variety of dinitrophenol 2 4 options are available to you, such as. Reason for citation 2, 4 dinitrophenol is on the hazardous substance list because it is cited by epa. The longer dnp is run, the higher %potential for adverse effects. A weight loss agent with significant acute toxicity and risk of death.
The lowest published lethal human oral dose of dnp is 4. If you subscribed, you got a bunch of audio cassettes containing interviews with 10 bodybuilding experts. Explodes if dried and exposed to heat, flame, friction or shock. Using 2,4dnp as a shell filling was less sensitive than picric acid on its own. The substance identifiers displayed in the infocard are the best available substance name, ec number, cas number andor the molecular and structural formulas. Incompatible with heavy metals and their compounds. Epa rfdrfc work group and determined to be inadequate for the derivation of an inhalation rfc. Looking for online definition of 2, 4 dinitrophenol in the medical dictionary. Warnings issued over deadly dnp diet drug thursday 19 september 20 tragedy of the gifted rugby player, 18, who died after buying deadly fatburning pills online, the daily mail reports. We report the cases of two individuals, one in tacoma, wa, and the second in san diego, ca, whose deaths were attributed to ingestion of 2,4dinitrophenol 2,4dnp. Uses the predominant use of 2,4dinitrotoluene is as an intermediate in the manufacture of polyurethanes. Dinitrophenol is an ionophoric compound that short circuits mitochondrial atp. A synthesis of 2,4dinitrophenol has been described.
This means that the energy from electron transfer cannot be used for atp synthesis. In bodybuilding, it is used for rapid fat loss, but its considered extremely dangerous when ingested. A toxic dye, chemically related to trinitrophenol picric acid, used in biochemical studies of oxidative processes where it uncouples oxidative. This is most of the info i used when i was researching dnp and some new stuff. The mechanism of uncoupling of oxidative phosphorylation by 2, 4dinitrophenol received for publication, january 18, 1967 gifford b.
The warning concerns 2,4dinitrophenol dnp, a combination of compounds that increases body temperature and metabolic rate. It is just of one of many newspapers and websites who have reported on the death of chris mapletoft, who died after taking 2,4dinitrophenol dnp. First aid measures general advice consult a physician. Dnp is used in developing photography, killing fungi, and as an industrial pesticide. Also incompatible with strong oxidizing agents, strong bases and reducing agents. Mitochondrial uncoupler prodrug of 2,4dinitrophenol, mp201. Polished semiprecious tumbled stones pictures are to provide an idea of the typical mix of sizes. This material does not contain any class 1 ozone depletors. Officially, while an industrial chemical dnp is pure poison.
It is used in dyes, photo developers, explosives, and as a preservative of lumber. Dnp 2, 4 dinitrophenol is a chemical product that was historically used as an antiseptic, herbicide, and explosive. Summary of 2, 4 dinitrophenol primary information, health benefits, side effects, usage, and other important details dinitrophenol is an ionophoric compound that short circuits mitochondrial atp production. The of and to a in for is on that by this with i you it github. Buy dnp 2,4dinitrophenol not for human consumption. Sep 17, 2015 buy dnp 2, 4 dinitrophenol not for human consumption. It uncouples oxidative phosphorylation by carrying protons across the mitochondrial membrane, leading to a rapid consumption of energy without generation of atp. Identification 2,4dinitrophenol is a yellow crystalline sandlike solid but is often found in a solution. Nevertheless, an explosion in a munitions factory at rainham in essex in 1916 was attributed to 2, 4 dinitrophenol. Can you do the design for us9 we can specially customize according to your technical requests.
Chronic longterm oral exposure to 2,4dinitrophenol in humans has resulted in the formation of cataracts and skin lesions, weight loss, and has caused effects. Some users have been known to run upwards of 1gday. Mitochondrial uncoupler prodrug of 2,4dinitrophenol. The benefits and side effects of dnp 2,4dinitrophenol. Dnp is an inhibitor of efficient energy atp production in cells with mitochondria. Full text full text is available as a scanned copy of the original print version.
The compound can often be found in pressure treated wood as a fungicide, in various dyes, used in photograph development and as an insecticide. New highly selective method is suggested for synthesis of 2,4dinitrophenol by nitration of phenol with nitric acid in an aqueousalcoholic medium at the boiling point of the reaction mixture. What is 2,4dnph and why are schools carrying out controlled. Dnp is known by its official name, 2,4dinitrophenol, and is considered an industrial chemical. A phenolate anion obtained from 2, 4 dinitrophenol. Dnp works via increasing heat production in cells via a process known as. Get a printable copy pdf file of the complete article 2.
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